Water Cooler Games
Water Cooler Games served as the web's primary forum for "videogames with an agenda" — coverage of the uses of video games in advertising, politics, education, and other everyday activities, outside the sphere of entertainment.

The site was maintained at watercoolergames.org from 2003-2009, where it was edited by myself and Gonzalo Frasca. It is now archived here in full.
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"Save the Whales" for Atari 2600
by Ian Bogost January 22, 2004

Apparently someone made a game for Atari 2600 called Save the Whales, whose proceeds were supposed to benefit Greenpeace. The game was never released (follow the link above for screenshots).

You control a submarine that must "Save the Whales" by shooting the harpoons or nets thrown by the ship at the top of the screen.  You can choose between harpoons or nets by changing the difficulty switch, harpoons are smaller and faster than the nets so they're harder to hit.  If a harpoon or net hits your sub you'll have some damage, if you take five hits it's game over and all the whales die!

(thanks to Clive for this one).